Work

Acidification of the interior of Ehrlich ascites tumor cells by nigericin inhibits DNA synthesis

Year: 1987

Type: article

Abstract: In Ehrlich ascites carcinoma cells, acidification of the cytoplasm down to pH 6.2-6.3 arrests DNA synthesis. Such acidification can be obtained by decreasing the pH outside the cell or, alternatively, by addition of a micromolar concentration of the K+/H+ antiporter nigericin. Thus, nigericin may be regarded as a new type of cytostatic, the effect of which is mediated by alteration of the intracellular pH.

Source: FEBS Letters

DOI: 10.1016/0014-5793(87)80831-1

Authors: L.B. Margolis, I.A. Rozovskaja, V.P. Skulachev

Institution: Lomonosov Moscow State University

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1973677934

FWCI: 0.519

Cites: 12

Cited by: 14

Related to: 10