Work

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

Year: 1975

Type: article

Abstract: Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.72.1.318

Authors: C M Wei, B Moss

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1973683758

FWCI: 53.88

Cites: 7

Cited by: 320

Related to: 10