Association of body mass index and risk of death from pancreas cancer in Asians
Year: 2012
Type: article
Abstract: We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥ 30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.
Authors: Yingsong Lin, Rong Fu, Eric Grant, Yu Chen, Jung Eun Lee, Prakash C. Gupta, Kunnambath Ramadas, Manami Inoue, Shoichiro Tsugane, Yu-Tang Gao, Akiko Tamakoshi, Xiao-Ou Shu, Kotaro Ozasa, Ichiro Tsuji, Masako Kakizaki, Hideo Tanaka, Chien-Jen Chen, Keun-Young Yoo, Yoon-Ok Ahn, Habibul Ahsan, Mangesh S. Pednekar, Catherine Sauvaget, Shizuka Sasazuki, Gong Yang, Yong-Bing Xiang, Waka Ohishi, Takashi Watanabe, Yoshikazu Nishino, Keitaro Matsuo, San-Lin You, Sue K. Park, Dong-Hyun Kim, Faruque Parvez, Betsy Rolland, Dale McLerran, Rashmi Sinha, Paolo Boffetta, Wei Zheng, Mark Thornquist, Ziding Feng, Daehee Kang, John D. Potter
Institutions: Aichi Medical University, Fred Hutch Cancer Center, New York University, Sookmyung Women's University, Healis Sekhsaria Institute For Public Health, National Cancer Centre Japan, Shanghai Cancer Institute, Hokkaido University, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tohoku University, Aichi Cancer Center, National Taiwan University, Chinese Academy of Sciences, Genomics Research Center, Academia Sinica, Seoul National University, University of Chicago, International Prevention Research Institute, Centre international de recherche sur le cancer, Massey University, Radiation Effects Research Foundation, Miyagi Prefectural Hospital Organization, National Defense Medical Center, Hallym University, Columbia University, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1973742082