Inactivation of Endotoxin by a Humoral Component. Vi. Two Separate Systems Required for Viable and Killed Salmonella Typhosa
Year: 1960
Type: article
Abstract: The blood of mammalian species contains a com-ponent which inactivates endotoxins in vitro (1). This endotoxin-detoxifying component (EDC) is identified by attributes which distinguish it from other substances in blood of known biologic ac-tivity (2, 3). Following appropriate interaction in vitro with this component, endotoxins from gram-negative bacteria are so altered that they no longer elicit such characteristic host reactions as the production of antibody (4), tumor damage, local skin reactivity and fatal shock. Bacterial endotoxins elicit the same host reactions which are evoked by the intact gram-negative bacilli from which they are isolated (5). It was therefore ex-pected that the endotoxin in its native state on
DOI: 10.1172/jci104046
Institution: National Cancer Institute
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1973843624