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Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

Year: 2012

Type: article

Abstract: A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.8.33

Authors: Raymond C F Jones, Abdul K Choudhury, James N Iley, Mark E Light, Georgia Loizou, Terence A Pillainayagam

Institutions: Loughborough University, The Open University, Engineering and Physical Sciences Research Council, University of Southampton

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Loughborough University, Engineering and Physical Sciences Research Council

OpenAlex ID: W1974152283