Work

Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond

Year: 2010

Type: article

Abstract: Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Source: Nano Letters

DOI: 10.1021/nl101140t

Authors: Rochelle R. Arvizo, Oscar R. Miranda, Michael A. Thompson, Christina M. Pabelick, Resham Bhattacharya, J. David Robertson, Vincent M. Rotello, Y. S. Prakash, Priyabrata Mukherjee

Institutions: Mayo Clinic, University of Massachusetts Amherst, University of Missouri

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1615300055, G2003936200, Molecular Mechanism of Antiangiogenic Properties of Gold Nanoparticle, G4018284648, Development of a gold nanoparticles based targeted delivery system, The Role of Caveolins in Lung Inflammation, G5900684841, Neurotrophins in the Lung, Rapid Multi-Channel Serum Profiling for Cardiac Disease using Fluorescent Nanosensors, G9000261190

OpenAlex ID: W1974302367

FWCI: 14.47

Cites: 30

Cited by: 621

Related to: 10