Work

Voxelwise Correlational Analyses of White Matter Integrity in Multiple Cognitive Domains in Schizophrenia

Year: 2006

Type: article

Abstract: Patients with schizophrenia show deficits in several neurocognitive domains. However, the relationship between white matter integrity and performance in these domains is poorly understood. The authors conducted neurocognitive testing and diffusion tensor imaging in 25 patients with schizophrenia. Performance was examined for tests of verbal declarative memory, attention, and executive function. Relationships between fractional anisotropy and cognitive performance were examined by using voxelwise correlational analyses. In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions.

Source: American Journal of Psychiatry

DOI: 10.1176/ajp.2006.163.11.2008

Authors: Kelvin O. Lim, Babak A. Ardekani, Jay Nierenberg, Pamela D. Butler, Daniel C. Javitt, Matthew J. Hoptman

Institution: University of Minnesota

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Alliance for Research on Schizophrenia and Depression, National Institutes of Health, National Institute of Mental Health