Work

Cyclin A Links c-Myc to Adhesion-independent Cell Proliferation

Year: 1995

Type: article

Abstract: Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.270.27.15923

Authors: John F. Barrett, Brian C. Lewis, Arthur T. Hoang, Rene J. Alvarez, Chi V. Dang

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430