Remodeling of Lipid Metabolism by Dietary Restriction of Essential Amino Acids
Year: 2013
Type: review
Abstract: All forms of life share the ability to sense envi-ronmental change and respond in real time byengaging adaptive homeostatic programs. Inhigher organisms, the composition of consumed meals presents a complex, constantly changing nutritional environment, and we are only beginning to understand the sensing and signaling systems that detect and coordinate the transcriptional, physiological, and behavioral respon-ses to meal components. Although it has long been axi-omatic that dietary composition plays a deterministic role in overall health, the growing prevalence of obesity and metabolic syndrome has prompted a refocus of attention on the significance of dietary macronutrients to health outcomes. Findings from earlier investigations of potential roles for dietary carbohydrates and fat in disease pro-gression or remediation (1–4) are now being reframed by experimental evidence linking dilution of dietary protein to compensatory increases in ingestive behavior (5,6). Recent
Source: Diabetes
DOI: 10.2337/db12-1613
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Mentoring Obesity and Diabetes Research in Louisiana, Coordinating and Bioinformatics Unit for the MMPC/DiaComp, Mechanisms of Metabolic Regulation by Dietary Methionine Restriction, Neural regulation of protein ingestion, Molecular Mechanisms of Adverse Metabolic Events by Asparaginase., Pennington/Louisiana NORC
OpenAlex ID: W1974634361