Polyphosphoester‐Based Cationic Nanoparticles Serendipitously Release Integral Biologically‐Active Components to Serve as Novel Degradable Inducible Nitric Oxide Synthase Inhibitors
Year: 2013
Type: article
Abstract: A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.
Source: Advanced Materials
Institutions: Washington University in St. Louis, Texas A&M University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1974719793