Work

Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

Year: 2012

Type: review

Abstract: Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.

Source: Molecular Endocrinology

DOI: 10.1210/me.2012-1107

Authors: T. E. Hickey, J. L. L. Robinson, J. S. Carroll, W. D. Tilley

Institutions: Hanson Institute, The University of Adelaide, University of Cambridge, Cancer Research UK

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze