Year: 1997
Type: review
Abstract: Calprotectin is a calcium binding heterocomplex protein consisting of two heavy and one light chain.' 2 It belongs to the S-100 protein family and is derived predominantly from neu- trophils and monocytes.'This protein is distributed in myelomonocytic cells, epithelial cells, and keratinocytes and in various tissues and fluids in the body,' and is a putative protective protein.3Calprotectin and its subunits appear to have regulatory functions in the inflammatory process,5 6 and various bio- Diagnostics R & D, logical functions including antimicrobial7-' and Nycomed Pharma AS, antiproliferative'° " activity have been ascribed PO Box 5012 Maj, to the protein.In acute phase inflammatory N-0301 Oslo, Norway reactions calprotectin is detectable in elevated B Johne amounts that, in some instances correlate to elevated levels of neutrophil granulocytes or Blood Bank and other inflammation parameters such as C reac- Imnunology and tive protein (CRP) or erythrocyte sedimenta- Transfusion Medicine, tion rate (ESR).'`-`Sander et al'5 found poor Ullevaal University correlation between calprotectin and CRP, Hospital, N-0407 Oslo, blood leucocytes, and ESR in life threateningNorway infections, thus suggesting that these para-M K Fagerhol meters reflect separate aspects of the inflamma-C F Naess-Andresen tory response.
Source: Molecular Pathology
DOI: 10.1136/mp.50.3.113
Language: English
Topic: S100 Proteins and Annexins
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1974861015