Work

Functional implications of tRNA Mimicry. Crystal Structure of Ribosome Recycling Factor

Year: 2000

Type: article

Abstract: Ribosome recycling factor (RRF) together with elongation factor G (EF-G) catalyses the fourth step of protein synthesis; ribosome recycling.In this step the posttranslocational complex is separated into its components.The crystal structure of Thermotoga maritima ribosome recycling factor (RRF) has been determined to 2.55 Å resolution. 1 RRF overlaps almost perfectly with a tRNA molecule except that the amino acid binding CCA end is missing.The mimicry suggests that RRF binds to the tRNA binding ribosomal A-site and is translocated to the P-site by EF-G.This mechanism is supported by studies of antibiotic action on the RRF reaction.

Source: Acta Crystallographica Section A Foundations of Crystallography

DOI: 10.1107/s0108767300022388

Authors: M. Selmer, S. Al-Karadaghi, G. Hirokawa, A. Kaji, A. Liljas

Institutions: Lund University, University of Pennsylvania

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1974916242

FWCI:

Cites: 1

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Related to: 10