Work

Infant Neutropenia Associated with Breastfeeding During Maternal Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV

Year: 2014

Type: article

Study design: Observational Study

Abstract: ; 93% received zidovudine-containing ART; infants received nevirapine up to 6 weeks and cotrimoxazole after 6 weeks. Among 84 infants at 19 weeks, 58% had hematologic toxicity; 44% had neutropenia and 23% had anemia. Breastfeeding was associated with 3.8-fold higher risk of neutropenia (RR 3.8, 95% CI 1.03-14.1, p = 0.008). Hematologic monitoring and PMTCT regimen selection are important for optimizing infant outcomes.

Source: Retrovirology Research and Treatment

DOI: 10.4137/rrt.s13267

Authors: Njuguna, Marie Reilly, Walter Jaoko, Christine Gichuhi, Gwen Ambler, Elizabeth Maleche-Obimbo, Barbara Lohman-Payne, Tomáš Hanke, Grace John-Stewart

Institutions: University of Nairobi, Karolinska Institutet, Kenya AIDS Vaccine Initiative, University of Washington, University of Oxford, Jenner Institute

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1211141729, G209787586, G378552126, Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMC

OpenAlex ID: W1975021014

FWCI: 0.216

Cites: 15

Cited by: 1

Related to: 10