Role of Placental Nutrient Sensing in Developmental Programming
Year: 2013
Type: article
Abstract: Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the supply of nutrients, oxygen, and methyl donors and alter the secretion of hormones and other signaling molecules into the fetal circulation. Thus, the placenta plays a critical role in modulating maternal-fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.
Source: Clinical Obstetrics & Gynecology
Authors: THOMAS JANSSON, THERESA L. POWELL
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Maternal pro-inflammatory status in obesity regulates placental function, Molecular Mechanisms Linking Placental Nutrient Sensing and Fetal Programming, G2737757659, Placental adiponectin signaling and fetal programming in maternal obesity, Trophoblast mTOR: a critical hub linking maternal nutrient supply to placental function, fetal growth and fetal islet function, G965671774
OpenAlex ID: W1975164000