Work

Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT

Year: 2010

Type: article

Abstract: SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

Source: American Journal of Neuroradiology

DOI: 10.3174/ajnr.a2152

Authors: T. Schneider, J. Hom, J. Bredno, J.W. Dankbaar, S.-C. Cheng, M. Wintermark

Institutions: University of California, San Francisco, University of Virginia Health System, University Medical Center Utrecht

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Center for Research Resources