Consistency ofMycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum
Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women. METHODS: Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs. Postpartum change in magnitude of IFN-γ response was determined using linear mixed models. RESULTS: Among 18 women with positive pregnancy IGRA, 15 (83%) had a subsequent positive IGRA; 9 (50%) were always positive, 3 (17%) were always negative, and 6 (33%) fluctuated between positive and negative IGRAs. Women with pregnancy IGRA IFN-γ>8 spot forming cells (SFCs)/well were more likely to have consistent postpartum IGRA response (odds ratio: 10.0; 95% confidence interval (CI): 0.9-117.0). Change in IFN-γ response over postpartum was 10.2 SFCs/well (95% CI: -1.5-21.8 SFCs/well). CONCLUSION: Pregnancy positive IGRAs were often maintained postpartum with increased consistency in women with higher baseline responses. There were modest increases in magnitude of IGRA responses postpartum.
DOI: 10.1155/2012/950650
Institutions: University of Washington, University of Nairobi
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $820
Funders: Firland Foundation, University of Washington, National Institutes of Health, U.S. Food and Drug Administration, Center for AIDS Research, University of Washington, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Center for Complementary and Alternative Medicine, Office of Research on Women's Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1323885547, Pediatric HIV-1 in Africa: Pathogenesis and Management, G2213881162, G2219438539, G3312951299, G3407947818, G3639217337, AIDS International Training and Research Program, G3985073149, G4847806209, G5161508283, Latent TB Detection and Implications in HIV-1 Infected Women and Their Children, G6625095162, G6868336159, G7303942949, G7791962275, G7850305827, G799009311, G8356647391, G9000186388, University of Washington/Fred Hutch Center for AIDS Research, Pediatric Scientist Development Program
OpenAlex ID: W1975215861