Work

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

Year: 2005

Type: review

Abstract: In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP heterodimer formation to achieve peak levels of signaling in spatially restricted patterns. Because these signaling pathway components are all conserved, these observations should shed light on how BMP signaling is modulated in vertebrate development.

Source: Development

DOI: 10.1242/dev.02214

Authors: Michael B. O'Connor, David Umulis, Hans G. Othmer, Seth S. Blair

Institutions: University of Minnesota, Howard Hughes Medical Institute, University of Wisconsin–Madison

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Dynamic Pattern in Chemically Reacting Systems, Regulating TGF-beta Signaling in Drosophila