Work

Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Year: 2014

Type: review

Abstract: High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

Source: Expert Review of Anticancer Therapy

DOI: 10.1586/14737140.2015.990889

Authors: Linda Foit, Francis J Giles, Leo I Gordon, Colby Shad Thaxton

Institutions: Northwestern University, Northwestern Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, International Institute for Nanotechnology

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Cancer Institute, Air Force Office of Scientific Research