Work

In vivo immediate early gene expression induced in intestinal and colonic mucosa by feeding

Year: 1991

Type: article

Abstract: Since the gut responds rapidly to food intake, the levels of expression of several immediate early genes were measured in mucosa from small and large intestine of rats starved for 3 days or refed. Within 1 h of refeeding, jejunal and ileal c-fos, jun B and zif/268 mRNA and colonic zif/268 dramatically increased. The zif/268 gene in jejunum corresponded in size to the full-length cDNA but, in ileum, an RNA band of about 1.2 kb in size increased greatly after feeding. This represents a physiologic in vivo model for the study of gene regulation associated with intestinal epithelial cellular responses to feeding.

Source: FEBS Letters

DOI: 10.1016/0014-5793(91)80025-x

Authors: Peter R. Holt, Raymond N. DuBois

Institutions: St. Luke's-Roosevelt Hospital Center, Columbia University, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Digestive system and related health

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Aging, National Cancer Institute