Tissue Engineering of Articular Cartilage with Biomimetic Zones
Year: 2009
Type: review
Abstract: Articular cartilage damage is a persistent and increasing problem with the aging population, and treatments to achieve biological repair or restoration remain a challenge. Cartilage tissue engineering approaches have been investigated for over 20 years, but have yet to achieve the consistency and effectiveness for widespread clinical use. One of the potential reasons for this is that the engineered tissues do not have or establish the normal zonal organization of cells and extracellular matrix that appears critical for normal tissue function. A number of approaches are being taken currently to engineer tissue that more closely mimics the organization of native articular cartilage. This review focuses on the zonal organization of native articular cartilage, strategies being used to develop such organization, the reorganization that occurs after culture or implantation, and future prospects for the tissue engineering of articular cartilage with biomimetic zones.
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Howard Hughes Medical Institute, AO Foundation, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, University of California, San Diego, Australian Research Council, Stichting voor de Technische Wetenschappen, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases
OpenAlex ID: W1975471671