Work

NHC-Catalyzed/Titanium(IV)−Mediated Highly Diastereo- and Enantioselective Dimerization of Enals

Year: 2011

Type: article

Abstract: An NHC-catalyzed, diastereo- and enantioselective dimerization of enals has been developed. The use of Ti(Oi-Pr)(4) is a key element for the reactivity and selectivity of this process. The cyclopentenes are obtained with high levels of diastereo- and enantioselectivity and their synthetic utility is demonstrated by functionalization of the product alkene.

Source: Organic Letters

DOI: 10.1021/ol103112v

Authors: Daniel T. Cohen, Benoit Cardinal-David, John M. Roberts, Amy A. Sarjeant, Karl A. Scheidt

Institutions: Northwestern University, Chemistry of Life Processes Institute

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G682315649