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56 * Falls and Dyspnea-related Disability Are Predictors of Mortality in Patients With Copd and Major Depression

Year: 2015

Type: conference-abstract

Abstract: Introduction: Chronic obstructive pulmonary disease (COPD) is a major cause of hospital admission. We examined mortality predictors in patients admitted with acute exacerbation of COPD (AECOPD) with major depression following discharge of inpatient rehabilitation in one year follow-up. We hypothesized that severity of depression would be a major predictor of mortality. Methods: We obtained baseline and clinical data from 138 AECOPD patients with major depression [mean age (SD) = 71 (8.1) years; 91 females]. All patients met criteria for major depression using the DSM-IV criteria. Depression severity was assessed using the 17 item Hamilton Rating Scale for Depression >14. Patients did not have cognitive impairment (Mini Mental State Examination <24). Dyspnea-related disability was quantified using the Pulmonary Functional Status and Dyspnoea Questionnaire (PFSDQ) and co-morbidity was measured using the Charlson comorbidity index. Following discharge of inpatient rehabilitation all patients were prospectively followed and survival/mortality at 52 weeks was documented using hospital notes, family physicians and relatives. Data was analysed using the multivariate Cox regression analysis.

Source: Age and Ageing

DOI: 10.1093/ageing/afv037