Work

Controversial aspects of oncogene-induced senescence

Year: 2012

Type: article

Abstract: Oncogene-induced senescence (OIS) is a fail-safe mechanism that is developed to suppress cell proliferation caused by aberrant activation of oncoproteins in normal cells. Most of the available literature considers senescence to be caused by activated RAS or RAF proteins. In the current review, we will discuss some of the controversial aspects of RAS- or RAF-induced senescence in different types of normal cells: are tumor suppressors important for OIS? What is the role of DNA damage in OIS? Are there different types of OIS?

Source: Cell Cycle

DOI: 10.4161/cc.22589

Authors: Anna Bianchi-Smiraglia, Mikhail A. Nikiforov

Institution: Roswell Park Comprehensive Cancer Center

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute