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Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine Dinoflagellate Karlodinium veneficum

Year: 2010

Type: article

Abstract: In an attempt to determine the cause of repeated fish kills in an estuarine aquaculture facility in Maryland, a toxin with hemolytic, cytotoxic, and ichthyotoxic properties, designated as karlotoxin-2 (KmTx2), was isolated from Karlodinium veneficum. The structure of KmTx2 was elucidated by means of detailed ID and 2D NMR spectra, including 2D INADEQUATE. The relative and absolute configurations of KmTx2 were determined using J-based configuration analysis and comparison of its degradation products with synthetic controls.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja9091853

Authors: Jiangnan Peng, Allen R. Place, Wesley Yoshida, Clemens Anklin, Mark T. Hamann

Institutions: University of Hawaiʻi at Mānoa, University of Mississippi, University of Maryland Biotechnology Institute

Language: English

Topic: Marine Toxins and Detection Methods

Subfield: Environmental Chemistry

Field: Environmental Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

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