Work

Using Jasplakinolide to Turn on Pathways that Enable the Isolation of New Chaetoglobosins from Phomospis asparagi

Year: 2005

Type: article

Abstract: The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

Source: Journal of Natural Products

DOI: 10.1021/np050293f

Authors: Omar E. Christian, Jennifer Compton, Keisha R. Christian, Susan L. Mooberry, Fredrick A. Valeriote, Phillip Crews

Institutions: Texas Biomedical Research Institute, Henry Ford Health, University of California, Santa Cruz, Henry Ford Hospital

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G1746619664, G678791680