Year: 2008
Type: article
Abstract: BACKGROUND: Although thiazides increase urinary sodium excretion, they also decrease urinary calcium excretion. Recent studies in our laboratory have shown that increased dietary salt significantly reduces interstitial fluid calcium in Dahl salt-sensitive (DS) rats, and this was associated with a rise in blood pressure and increased urinary calcium excretion. Owing to the vasorelaxant actions of increased extracellular fluid calcium, we reasoned that the antihypertensive action of hydrochlorothiazide (HCTZ), a commonly used thiazide, may be the result of increased interstitial fluid calcium as a consequence of decreased urinary calcium excretion. METHODS: To test this hypothesis, DS and Dahl salt-resistant (DR) rats were given high salt alone or in combination with HCTZ for 1 week. Renal cortical interstitial fluid calcium was determined by the zero net flux method. RESULTS: High salt decreased cortical interstitial fluid calcium (1.69 +/- 0.25 vs. 1.13 +/- 0.05 mmol/l; P < 0.05) in DS rats as previously reported; thiazide treatment had no effect on the high salt interstitial fluid calcium response in salt-sensitive animals. However, thiazide decreased interstitial fluid calcium in DS on a normal salt diet. Cortical interstitial fluid calcium was unchanged by dietary salt in DR rats, and thiazide did not alter this interstitial fluid calcium response. CONCLUSION: We interpret these data to mean that (i) short-term thiazide treatment does not reduce blood pressure by restoring renal cortical interstitial fluid calcium concentration and (ii) a decrease in renal cortical interstitial fluid calcium may not contribute to the increased renal vasoconstriction seen in salt-sensitivity.
Source: American Journal of Hypertension
DOI: 10.1038/ajh.2008.158
Authors: S. L. Eley, C. M. Allen, C. L. Williams, R. D. Bukoski, M. A. Pointer
Institution: North Carolina Central University
Language: English
Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
Awards: G3403166545, Mechanisms Linking Ca2+ Homeostasis & Vascular Tone, G3499744517, NCCU Center for Translational Health Equality Research, NCCU-WFU BIOMEDICAL BRIDGE TO THE Ph.D. PARTNERSHIP, G7041982963, G7055995907, CARDIOVASCULAR HEALTH AMONG AFRICAN AMERICANS, Cardiovascular Health Among African Americans
OpenAlex ID: W1975672879