FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Year: 2011
Type: article
Abstract: Fibroblast growth factor (FGF) 19 is an enterokine synthesized and released when bile acids are taken up into the ileum. We show that FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. Mice lacking FGF15 (the mouse FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial amounts of liver glycogen. FGF19 treatment restored the loss of glycogen in diabetic animals lacking insulin. Thus, FGF19 activates a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
Source: Science
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Mechanisms of Lipid-Induced Hepatic Insulin Resistance, Yale Mouse Metabolic Phenotyping Center, Coordinating and Bioinformatics Unit for the MMPC/DiaComp, Nuclear Receptors and Coregulators in Health and Disease, Genetic and Cellular Mechanisms of NAFLD and Hepatic Insulin Resistance, Tissue-specific Mechanism of Action of the Metabolic Hormones FGF19 and FGF21, Yale Diabetes Research Center
OpenAlex ID: W1975673963