Work

Synthesis of QS‐21‐Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS‐21 Adjuvant with a Melanoma Vaccine

Year: 2008

Type: article

Abstract: A helping hand: The adjuvant QS-21-xylose (see structure; the xylose residue is shown in red) was obtained in pure form by chemical synthesis. When combined with its synthetic apiose isomer to furnish synthetic QS-21 (sQS-21), the saponin combination was shown to aid the production of antibodies in mice when injected with a melanoma vaccine. The preparation of sQS-21 provides access to pure, functional saponin adjuvants of defined composition.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200801885

Authors: Kai Deng, Michelle M. Adams, Payal Damani, Philip O. Livingston, Govind Ragupathi, David Y. Gin

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Natural product bioactivities and synthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences