Work

Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

Year: 2009

Type: article

Abstract: ST-246, a potent orthopoxvirus egress inhibitor, is safe and effective at preventing disease and death in studies of small-animal models involving challenge by several different pathogenic poxviruses. In this report, the antiviral efficacy of ST-246 in treatment of nonhuman primates infected with variola virus or monkeypox virus was assessed. The data indicate that oral dosing once per day with ST-246 protects animals from poxvirus disease, as measured by reductions in viral load and numbers of lesions and enhancement of survival.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00021-09

Authors: John Huggins, Arthur Goff, Lisa Hensley, Eric Mucker, Josh Shamblin, Carly Wlazlowski, Wendy Johnson, Jennifer Chapman, Tom Larsen, Nancy Twenhafel, Kevin Karem, Inger K. Damon, Chelsea M. Byrd, Tove' C. Bolken, Robert Jordan, Dennis Hruby

Institutions: United States Army Medical Research Institute of Infectious Diseases, Centers for Disease Control and Prevention, Siga Technologies (United States)

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1975853383

FWCI: 4.851

Cites: 25

Cited by: 176

Related to: 10