Work

The substrates and binding partners of protein kinase Cε

Year: 2010

Type: review

Abstract: The epsilon isoform of protein kinase C (PKCepsilon) has important roles in the function of the cardiac, immune and nervous systems. As a result of its diverse actions, PKCepsilon is the target of active drug-discovery programmes. A major research focus is to identify signalling cascades that include PKCepsilon and the substrates that PKCepsilon regulates. In the present review, we identify and discuss those proteins that have been conclusively shown to be direct substrates of PKCepsilon by the best currently available means. We will also describe binding partners that anchor PKCepsilon near its substrates. We review the consequences of substrate phosphorylation and discuss cellular mechanisms by which target specificity is achieved. We begin with a brief overview of the biology of PKCepsilon and methods for substrate identification, and proceed with a discussion of substrate categories to identify common themes that emerge and how these may be used to guide future studies.

Source: Biochemical Journal

DOI: 10.1042/bj20091302

Authors: Philip M. Newton, Robert O. Messing

Institutions: Swansea University, University of California, San Francisco, Ernest Gallo Clinic and Research Center

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke