Comprehensive Examination of Frontal Regions in Boys and Girls with Attention-Deficit/Hyperactivity Disorder
Year: 2011
Type: article
Study design: Observational Study
Abstract: The current study examined regional frontal lobe volumes based on functionally relevant subdivisions in contemporaneously recruited samples of boys and girls with and without attention-deficit/hyperactivity disorder (ADHD). Forty-four boys (21 ADHD, 23 control) and 42 girls (21 ADHD, 21 control), ages 8-13 years, participated. Sulcal-gyral landmarks were used to manually delimit functionally relevant regions within the frontal lobe: primary motor cortex, anterior cingulate, deep white matter, premotor regions [supplementary motor complex (SMC), frontal eye field, lateral premotor cortex (LPM)], and prefrontal cortex (PFC) regions [medial PFC, dorsolateral PFC (DLPFC), inferior PFC, lateral orbitofrontal cortex (OFC), and medial OFC]. Compared to sex-matched controls, boys and girls with ADHD showed reduced volumes (gray and white matter) in the left SMC. Conversely, girls (but not boys) with ADHD showed reduced gray matter volume in left LPM; while boys (but not girls) with ADHD showed reduced white matter volume in left medial PFC. Reduced left SMC gray matter volumes predicted increased go/no-go commission rate in children with ADHD. Reduced left LPM gray matter volumes predicted increased go/no-go variability, but only among girls with ADHD. Results highlight different patterns of anomalous frontal lobe development among boys and girls with ADHD beyond that detected by measuring whole lobar volumes.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Johns Hopkins University, National Institutes of Health, Institute for Clinical and Translational Research, University of Wisconsin, Madison, U.S. Public Health Service, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Institute for Clinical and Translational Research (UL1), G3281356711, Resource for Quantitative Functional FMRI, Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD, Mental Retardation and Developmental Disabilities Research Centers 2008, 2/2 - Anomalous Motor System Physiology in ADHD: Biomarker Validation and Modeling Domains of Function, Motor Skill Learning in Autism, ADHD in Girls: Neuroimaging and Executive Behavior
OpenAlex ID: W1976082807