Work

Science to Practice: Can Decreased Lymph Node MR Imaging Signal Intensity Be Used as a Biomarker for the Efficacy of Cancer Vaccination?

Year: 2014

Type: editorial

Abstract: Summary In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.

Source: Radiology

DOI: 10.1148/radiol.14142331

Author: Jeff W. M. Bulte

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute