A randomized, double-blind, controlled trial to evaluate the safety and immunogenicity of killed oral cholera vaccine (Shanchol®) in healthy individuals in Ethiopia
Year: 2014
Type: article
Study design: Clinical Trial
Abstract: Background: The WHO has prequalified a killed oral cholera vaccine (OCV) in 2011, which has been a key measure in facilitating its use as part of a comprehensive package including water and sanitation measures to cholera epidemic affected areas such as Guinea and Haiti. A recent phase 3 trial enrolling approximately 70,000 adults and children in India demonstrated a 65% cumulative protective efficacy over 5 years. This is the first trial to evaluate the safety and immunogenicity of a two dose OCV regimen in an African population.
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W1976337590