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Reply to: “Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients”

Year: 2012

Type: letter

Abstract: We thank Dr. Valenti et al. for raising an additional point that PNPLA3 might be associated with steatosis in the setting of HCV infection after controlling for IL28B [1]. They demonstrate in their cohort of 567 treatment naïve patients that both IL28B (rs12979860) and PNPLA3 (rs738409) may contribute to steatosis. Furthermore, in their study the beneficial effect of IL28B was limited to the patients without the PNPLA3 risk allele “G” as rs738409. A role of PNPLA3 GG genotype for steatosis in HCV infected patients has been observed in several studies, especially when excluding genotype 3 patients [2–5].

Source: Journal of Hepatology

DOI: 10.1016/j.jhep.2011.12.003

Authors: Eric Trépo, Pierre Pradat, Jeanette J. McCarthy, Hans L. Tillmann

Institutions: Université Libre de Bruxelles, Erasmus Hospital, Hôtel-Dieu de Lyon, Duke Medical Center, Duke Clinical Research Institute

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,500

OpenAlex ID: W1976500969

Cites: 7

Cited by: 2

Related to: 10