Work

miR-122, a paradigm for the role of microRNAs in the liver

Year: 2008

Type: article

Abstract: Recent studies have uncovered profound and unexpected roles for a family of tiny regulatory RNAs, known as microRNAs (miRNAs), in the control of diverse aspects of hepatic function and dysfunction, including hepatocyte growth, stress response, metabolism, viral infection and proliferation, gene expression, and maintenance of hepatic phenotype. In liver cancer, misexpression of specific miRNAs suggests diagnostic and prognostic significance. Here, we review the biology of the most abundant miRNA in human liver, miR-122, and consider the diversity of its roles in the liver. We provide a compilation of all miRNAs expressed in the liver, and consider some possible therapeutic opportunities for exploiting miRNAs in the different settings of liver diseases.

Source: Journal of Hepatology

DOI: 10.1016/j.jhep.2008.01.019

Authors: Muriel Girard, Emmanuel Jacquemin, Arnold Munnich, Stanislas Lyonnet, Alexandra Henrion-Caude

Institutions: Hôpital Necker-Enfants Malades, Inserm, Assistance Publique – Hôpitaux de Paris, Université Paris Descartes, Bicêtre Hospital

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,500