Year: 2011
Type: article
Abstract: We describe MarkUs, a web server for analysis and comparison of the structural and functional properties of proteins. In contrast to a 'structure in/function out' approach to protein function annotation, the server is designed to be highly interactive and to allow flexibility in the examination of possible functions, suggested either automatically by various similarity measures or specified by a user directly. This is combined with tools that allow a user to assess independently whether or not a suggested function is consistent with the bioinformatic and biophysical properties of a given query structure, further allowing the user to generate testable hypotheses. The server is available at http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:Mark-Us.
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkr468
Authors: M. Fischer, Q. C. Zhang, F. Dey, B. Y. Chen, B. Honig, D. Petrey
Institutions: Howard Hughes Medical Institute, Columbia University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,992
OpenAlex ID: W1976697716