Work

Aspects of B‐Cell Non‐Hodgkin’s Lymphoma Development: A Transition from Immune‐Reactivity to Malignancy

Year: 2009

Type: review

Abstract: The development of B-cell lymphomas is an intricate interplay among various pathogenic factors, leading to a multi-step process, encompassing various stages of B-cell maturation. Besides genetic abnormalities, a variety of environmental and microbial factors, as well as disproportional immune-regulatory processes lead to the malignant transformation. Yet, little is known about the exact chain of events, which lead from the physiological polyclonal B-cell activation as a response to exogenous antigens through oligoclonality to a monoclonal, uncontrolled, malignant B-cell proliferation. The aim of the present review was to summarize the potential harmful steps in the development of B-cell lymphomas, according to conventional and novel theories, and to depict therapeutic regimens presently in use as well as to envision future drug developments, beneficial in the battle against this lymphoid malignancy.

Source: Scandinavian Journal of Immunology

DOI: 10.1111/j.1365-3083.2009.02237.x

Authors: A. Illes, L. Varoczy, G. Papp, P. C. Wilson, P. Alex, R. Jonsson, T. Kovacs, Y. T. Konttinen, M. Zeher, B. Nakken, P. Szodoray

Institutions: University of Debrecen, University of Chicago, Johns Hopkins University, Johns Hopkins Medicine, University of Bergen, Helsinki University Hospital, Coxa Hospital, Tekonivelsairaala Orton, University of Oslo

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1976734177

FWCI: 0.315

Cites: 146

Cited by: 26

Related to: 10