Work

Embryonic origin of the adult hematopoietic system: advances and questions

Year: 2011

Type: review

Abstract: Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

Source: Development

DOI: 10.1242/dev.040998

Authors: Alexander Medvinsky, Stanislav Rybtsov, Samir Taoudi

Institutions: MRC Centre for Regenerative Medicine, University of Edinburgh, Walter and Eliza Hall Institute of Medical Research

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Wellcome Trust, Leukaemia and Lymphoma Research, Medical Research Council, Biotechnology and Biological Sciences Research Council

Awards: G359049464, The analysis of cellular mechanisms underlying haematopoietic stem cell (HSC) development using a novel in vitro system, Identification of functional domains in the AGM region linked to the hierarchical organisation of the developing haematopoietic stem cell lineage