Work

miRNA-mediated GALNT modulation of invasion and immune suppression

Year: 2012

Type: article

Abstract: Glycosylation is a key process impacting on many aspects of cellular interactions. We recently reported that a miRNA cluster controls glycosylation by directly targeting N-acetylgalactosamine transferases (GALNTs), resulting in increased tumor invasion and immunosuppression. Here we further discuss how defective glycosylation or GALNTs dysregulation may contribute to tumor progression.

Source: OncoImmunology

DOI: 10.4161/onci.19535

Authors: Avital Gaziel-Sovran, Eva Hernando

Institution: New York University

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913