Correlation of lung mechanics with saturated phosphatidylcholine ratios and surfactant protein A in bronchoalveolar lavage fluid from infants with RSV induced respiratory failure
Year: 1999
Type: conference-abstract
Abstract: Nineteen infants were studied, median age 7 weeks (range 3–25 weeks), median weight 4 kg (range 2–6 kg). BALs were taken within 24 h of commencing mechanical ventilation. BAL surfactant phospholipid composition was detected by electrospray ionization mass spectrometry, and SPA levels by enzyme-linked immunosorbent assay. Static respiratory system compliance and resistance were measured using the single breath occlusion technique with a commercially available device (PEDS 4.1, Medical Associated Services, USA). The median (interquartile range) values for compliance 0.36 (0.31–0.47) ml/cmH 2 O/kg, and resistance 234 (184–277) cmH 2 O/l/s. The DPPC/POPC ratio correlated significantly with both compliance and resistance (see Figure). There was no correlation (neither linear nor exponential) between SPA/DPPC ratio and lung mechanics (compliance: r = 0.1, resistance r = 0.24). Surfactant containing higher ratios of saturated phosphatidylcholine has a role in maintaining compliance and small airway patency in RSV infected infants. Although a certain minimal level of SPA is necessary for surfactant function, additional benefit is not seen with increasing SPA/DPPC ratios. These findings have implications for exogenous surfactant supplementation in this disease.
Source: Critical Care
DOI: 10.1186/cc420
Institution: Guy's Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W1976820596