Work

The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct

Year: 1999

Type: article

Abstract: The assumption that reversible inhibition of mitochondrial respiration by nitric oxide (NO.) represents inhibition of ATP synthesis is unproven. NO. could theoretically inhibit the oxygen consumption with continued ATP synthesis, by acting as an electron acceptor from cytochrome c or as a terminal electron acceptor in stead of oxygen. We report here that NO. does reversibly inhibit brain mitochondrial ATP synthesis with a time course similar to its inhibition of respiration. Whilst such inhibition was largely reversible, there appeared to be a small irreversible component which may theoretically be due to peroxynitrite formation, i.e. as a result of the reaction between NO. and superoxide, generated by the mitochondrial respiratory chain.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(99)00217-3

Authors: Paul S. Brookes, Juan P. Bolaños, Simon J.R. Heales

Institutions: University of Alabama at Birmingham, Universidad de Salamanca, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1976919047

FWCI: 2.985

Cites: 25

Cited by: 93

Related to: 10