Year: 2012
Type: review
Abstract: The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C(3)H(2)C(3) type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.
Source: FEBS Letters
Authors: Yong-Sam Jung, Yingjuan Qian, Xinbin Chen
Institution: University of California, Davis
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Mechanism of p53-dependent tumor suppression, G373753221, Mechanism of p63-Dependent Tumor Suppression, G5359806256, Regulation of Mutant P53 Expression and Oncogenic Activity, The role of DNA polymerase eta in DNA damage response and p53 activation, G7699231328, Mechanism of P73-dependent Tumor Suppression, MECHANISM OF P53 DEPENDENT APOPTOSIS, G9000135920, G938690596
OpenAlex ID: W1976975610