Nongenomic Actions of Adrenal Steroids in the Central Nervous System
Year: 2010
Type: review
Abstract: Mineralocorticoids and glucocorticoids are steroid hormones that are released by the adrenal cortex in response to stress and hydromineral imbalance. Historically, adrenocorticosteroid actions are attributed to effects on gene transcription. More recently, however, it has become clear that genome-independent pathways represent an important facet of adrenal steroid actions. These hormones exert nongenomic effects throughout the body, although a significant portion of their actions are specific to the central nervous system. These actions are mediated by a variety of signalling pathways, and lead to physiologically meaningful events in vitro and in vivo. We review the nongenomic effects of adrenal steroids in the central nervous system at the levels of behaviour, neural system activity, individual neurone activity and subcellular signalling activity. A clearer understanding of adrenal steroid activity in the central nervous system will lead to a better ability to treat human disease as well as reduce the side-effects of the steroid treatments already in use.
Source: Journal of Neuroendocrinology
Institution: University of Cincinnati
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: green
Awards: G1192369509, Central Angiotensin receptors and teh neural control of homeostasis, Central AT1 receptors and the integrated stress response., G3870759367, GENOMIC &NONGENOMIC EFFECTS OF STEROIDS ON SALT INTAKE, G5723499059, The effect of AT1R antisense on centrally-mediated responses to angiotension II, Stress and Body Weight Regulation, Anatomical Plasticity and HPA Axis Dysfunction, Predoctoral Training Program in the Neurosciences, GENOMIC &NONGENOMIC EFFECTS OF STEROIDS ON SALT INTAKE
OpenAlex ID: W1977011758