Work

Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks

Year: 2006
Type: article
Abstract: T he prevalence of obesity has risen substantially during the past 25 years in the United States and most developed countries, with a related increase in type 2 diabetes mellitus.1,2 Almost one third of the adult US population is considered to be obese (body mass index [BMI] Ն30), and 1 in 20 is extremely obese (BMI Ն40). 3 Nearly 17% of children and adolescents are overweight in the United States.3 Obesity is associated with increased risk for type 2 diabetes mellitus, coronary heart disease (CHD), hypertension, obstructive sleep apnea, and cancer, higher overall mortality rate, 4 -6 and decreased longevity.7,8 Extreme obesity can truncate life expectancy in young adults by 5 to 20 years.8 Accordingly, the expected benefits of weight reduction for obese individuals are profound.
Source: Circulation
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W1977055629
FWCI: 8.299
Cites: 89
Cited by: 76
Related to: 10