Work

WARP is a new member of the von Willebrand factor A‐domain superfamily of extracellular matrix proteins

Year: 2002

Type: article

Abstract: We report a new member of the von Willebrand factor A-domain protein superfamily, WARP (for von Willebrand factor A-domain-related protein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment. WARP mRNA was expressed predominantly in chondrocytes and in vitro expression experiments in transfected 293 cells indicated that WARP is a secreted glycoprotein that forms disulphide-bonded oligomers. We conclude that WARP is a new member of the von Willebrand factor A-domain (VA-domain) superfamily of extracellular matrix proteins which may play a role in cartilage structure and function.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(02)02579-6

Authors: Jamie Fitzgerald, Su Tay Ting, John F. Bateman

Institutions: Royal Children's Hospital, The University of Melbourne, Murdoch Children's Research Institute

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Medical Research Council, National Health and Medical Research Council