Work

Effect of Transfer Factor Therapy on Mixed Lymphocyte Culture Reactivity

Year: 1974

Type: article

Abstract: We have studied the effect of dialyzable transfer factor therapy on three patients with immunodeficiency disease and in one patient who demonstrated no evidence of deficiency of either humoral or cellular immunity. We found evidence for nonspecificity in the effect of transfer factor on mixed lymphocyte culture reactivity. The data suggest that in patients with immunodeficiency disease a maturation of lymphocytes may lead to a generalized increased immune responsiveness. More profoundly, our data show that transfer factor may induce changes in the expression of histocompatibility determinants. We observed changes in the expression of determinants capable of stimulating in the mixed lymphocyte culture reaction as well as an increase in the capacity of lymphocytes to respond.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.71.3.867

Authors: Bo Dupont, Mark Ballow, John A. Hansen, Cedric Quick, Edmond J. Yunis, Robert A. Good

Institutions: Memorial Sloan Kettering Cancer Center, University of Minnesota

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: March of Dimes Foundation, Hartford Foundation for Public Giving, U.S. Public Health Service, National Cancer Institute