Work

Pentose-phosphate pathway disruption in the pathogenesis of Parkinson’s disease

Year: 2014

Type: article

Abstract: Oxidative stress is known to be a key factor in the pathogenesis of Parkinson’s disease (PD). Neuronal redox status is maintained by glucose metabolism via the pentose-phosphate pathway and it is known that disruption of glucose metabolism is damaging to neurons. Accumulating evidence supports the idea that glucose metabolism is altered in PD and dysregulation of the pentose-phosphate pathway in this disease has recently been shown. In this review, we present an overview of the literature regarding neuronal glucose metabolism and PD, and discuss the implications of these findings for PD pathogenesis and possible future therapeutic avenues.

Source: Translational Neuroscience

DOI: 10.2478/s13380-014-0221-y

Authors: Laura Dunn, Vanessa Fairfield, Shanay Daham, Juan Bolaños, Simon Heales