Work

Signaling networks of Rho GTPases in cell motility

Year: 2013

Type: review

Abstract: The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.

Source: Cellular Signalling

DOI: 10.1016/j.cellsig.2013.04.009

Authors: Samer Hanna, Mirvat El-Sibai

Institution: Lebanese American University

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550