Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration
Year: 2006
Type: article
Study design: Observational Study
Abstract: The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (Abeta40) and amyloid beta 1-42 (Abeta42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease (AD, n = 39) and in control subjects (n = 30). While in AD cases Abeta42 levels were lower and CSF Abeta40 levels equal to those in controls, a significant decrease in Abeta40 and increase in the CSF Abeta42/Abeta40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid beta peptides in FTLD compared with AD.
Authors: Y A L Pijnenburg, S N M Schoonenboom, P D Mehta, S P Mehta, C Mulder, R Veerhuis, M A Blankenstein, P Scheltens
Institution: Amsterdam UMC Location Vrije Universiteit Amsterdam
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1977559338